B.S., Chemistry, Villanova University
M.S., Chemistry, Villanova University
Ph.D., Microbiology, University of Alabama, Birmingham
The use of photosynthetic bacteria to produce commodity chemicals and fuels allows for a more sustainable and environmentally friendly alternative to industrial fermentation. However, in order to compete economically with standard processes, specific challenges like light limitation and discontinuous productivities due to diurnal cycles necessitate a thorough understanding of the molecular biology in these organisms. Yet, basic genetic tools are limited in cyanobacteria compared to well-studied organisms. I therefore develop tools in Synechococcus sp. PCC 7002; enabling the use of this fast growing cyanobacterium as a cellular factory.
Jones, C.M., Hernandez Lozada, N.J., Pfleger, B.F., 2015. Efflux systems in bacteria and their metabolic engineering applications. Applied microbiology and biotechnology, 2015. 99, 9381-9393.
Jones, C.M., Wells, R.M., Madduri, A.V.R., Renfrow, M.B., Ratledge, C., Moody, D.B. and M. Niederweis, Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling Proceedings of the National Academy of Sciences of the United States of America, 2014. 111(5): p. 1945-1950.
Wells, R.M., Jones, C.M., Xi, Z., Speer, A., Danilchanka, O., Doornbos, K.S., Sun, P., Wu, F., Tian, C. and M. Niederweis, Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis PLoS Pathogens, 2013. 9(1): e1003120.
Jones, C.M. and M. Niederweis, Mycobacterium tuberculosis can utilize Heme as an iron source. J Bacteriol, 2011. 193(7): p.1767-70.
Jones, C.M. and M. Niederweis, Role of porins in iron uptake by Mycobacterium smegmatis. J Bacteriol, 2010. 192(24): p.6411-7.